Drug discovery Conference

    Drug development is a term used to define the entire process of bringing a new drug or device to market. It is an integrated, multidisciplinary endeavor that includes drug discovery, chemistry and pharmacology, nonclinical safety testing, manufacturing, clinical trials, and regulatory submissions. This report summarizes presentations of a workshop entitled "Drug Development 101," held at the 39th Annual Meeting of the American College of Toxicology in West Palm Beach, Florida. The workshop was designed to provide an introductory overview of drug development. Experienced scientists from industry and government provided overviews of each area, with a focus on safety assessment, and described some of the challenges that can arise. The role of chemistry and manufacturing was discussed in the context of early- and late-stage product development and approaches to assess, control, and limit impurities. The toxicologic assessment was emphasized in early-phase development, from th...

  The value of using the RO3 in FBDD is being (correctly) challenged4 as many useful fragment hits do not adhere to its restrictions (see the Practical Fragments blog website). We have always believed that the RO3 concept has limitations and, like other rules related to desirable physicochemical properties, such as the 'rule of five' guidelines5, it is simply a guideline that should not be overemphasized. Nevertheless, we believe that the RO3 has been useful in ensuring that fragment libraries really do consist of compounds with fragment-like properties, although reports of 'fragment' hits that actually resemble lead-like compounds — particularly considering their substantial molecular mass — do still appear. The fundamental concept of fragment screening is to use simpler molecules so that the chemical space can be sampled much more efficiently than is possible when using molecules of greater complexity6. One consequence of screening smaller, simpler fragments is that t...

  As such, one of the most important steps in developing a new drug is  target identification and validation . A target is a broad term which can be applied to a range of biological entities which may include for example proteins, genes and RNA. To know more about drug discovery join with us at drug discovery 2023 which is going to be held at  September 21-22, 2023  Paris, France for more details :  Drug discovery conference